Tuesday, December 24, 2019

Human Development and the Importance of Wind Energy...

Human Development and the Importance of Wind Energy Conversion For human development to continue, we will ultimately need to find sources of renewable or virtually inexhaustible energy. Its difficult to imagine this, but even if we find several hundred or even thousand years of coal and natural gas supplies, what will humans do for the next 250,000 years or so after they are depleted? Even the most apparently inexhaustible sources like fusion involve the generation of large amounts of waste heat -- enough to place damaging stress on even a robust ecosystem like Earths, at least for the organisms that depend upon stability of the system to survive. We are engaged in a sort of world-wide biological experiment, with our descendents†¦show more content†¦We are blissfully sedated by low conventional energy prices and are gulping down the few remaining years of cheap natural gas and Mid East oil. As we do this, the inertia of global warming is inexorably building. What drives the continued development of mechanical devices like wind turbines in the face of this widespread lack of support? In the case of wind turbine technology, I suspect that part of the reason for persistence of this vision is how accessible wind turbines are to the understanding. They are personal in a way that almost no other form of power generation is. This personal scale has been both the blessing and the curse of wind power development. The field tends to attract people who are committed, creative, and passionate. It also attracts a few people who are a little too much of all of those things, to the point that sometimes the grounding of reality is lost. Both of these tendencies will be evident in this brief history of wind power development. Wind power will probably succeed or fail based on the ability or inability of its proponents to bank the fires of Romance and focus on defining wind generations role as a practical alternative to conventional generation sources. Wind energy conversion is a fascinating field to study, if only because its past has been so checkered and its exact future is so uncertain. Unlike the aerospace industry, the computer industry, and almost any other successful industry you can name, wind energy -- theShow MoreRelatedHigh Capacity Unit And Network1048 Words   |  5 Pagesmaterials to increase one aspect but also the future development. c Grid technology. Focus on high-capacity unit and network, but can also focus on the development of small-capacity unit. Small-capacity units and network are more difficult, but it can be other power generation combined. 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A basic extent of the evolution of society is directly associated with the changes in the fundamental sources of energy and its uses. Through the last 250 years, people have learned how to harvest and deal with energy in different forms to make work easier and live more comfortable. Nevertheless, this human activity is overloading the atmosphere with greenhouse gases emission, which make the temperature higherRead MoreThe Concept Of Sustainable Development Essay1654 Words   |  7 PagesThe concept of sustainable development is generally understood in two similar but differing perspectives. The first of these is the social-scientific definition explicated most frequently in relation to the 1987 report of the Brundtland commission.1 This report defines sustainable development as our â€Å"...ability to make development sustainable—to ensure that it meets the needs of the present without compromising the ability of future generations to meet their own needs†2. The second perspective

Sunday, December 15, 2019

The pathogenesis of measles virus infection Free Essays

string(86) " infects cells of the immune system, monocytes are the mostly affected cells \(6,7\)\." Introduction Measles is one of the most important contagious diseases of mankind. It remains one of the leading causes of infant deaths in developing countries (1). In 1998 the world health organisation (WHO) estimated that despite all the efforts to eradicate measles it still accounted for more than 30 million infections and 1 million deaths every year (2). We will write a custom essay sample on The pathogenesis of measles virus infection or any similar topic only for you Order Now Most of infections, it is believed are from countries where vaccination has not been taken up properly and developing countries where vaccination programmes are not that robust. Measles is very infections with an infection rate of 90% (3) when susceptible individuals are exposed to the organism that causes measles. This organism is an RNA virus of the genus morbillivirus, hence measles sometimes being referred to as morbilli. This virus belongs to the virus family of the Paramyxoviridae (4). The measles virus is transmitted through bodily fluids mainly as aerosols (airborne exposure) or droplets (5). It enters the host through the respiratory tract and immediately starts to replicate in the epithelial cells of the respiratory tract (6), from here the virus start to invade some cells of the immune system in the lymph nodes particularly the monocytes (7) through which it then spreads to rest of the host body. Measles is a self limiting disease, which means it will normally resolve itself after a few weeks, but because measles also induces a transient profound immunosupression (8), most of its victims succumb to fatal opportunistic infections. Without these infections the host will normally clear the virus from its system as illustrated by the graph below. Fig. 1. Pathogenesis of measles in-host. The level of measles virus in the plasma is plotted versus day of infection (7) It should be noted that in very rare cases the measles virus cannot be cleared from the host and persist in the host system in what is termed persistent measles virus (PMV). This is the cause of most measles complications which includes a subacute sclerosing pan encephalitis (SSPE) (5)(9) which may occur in about 1:10 000 measles cases (9) and inclusion encephalitis (5) which may occur if the host does not have adequate cellular response to the infection. Infection and Spread Clinical symptoms of measles include fever, malaise, coryza (runny nose), conjunctivitis and tracheobronchitis (10). Other symptoms that appear at a later stage during infection are the Koplik’s spots, 10-12 days post exposure, and erythmatous maculopapular rash which appears at around day 14 (5). Symptoms like diarrhoea and pneumonia, which are from opportunistic infections, will not be discussed here as they are not a direct result of the measles virus. The direct results will be discussed later in this essay after discussing how the virus infects and spread around the host body. To fully understand the mechanism of measles virus infection, one has to understand the measles virus structure. The virus As a morbillivirus in the paramyxoviridae family, the measles virus is a negative, single strand enveloped RNA virus (11). It is about 150-300 nm in diameter and has a lipid bilayer surrounding the RNA forming the envelope. Protruding from this envelope are two glycoprotein ligands called haemagglutinin (H) and fusion (F), necessary for virus attachment to host cells. The RNA is enclosed in a nucleoprotein (N) and associated with two proteins called phosphoprotein (P) and large protein (L) (12). See diagram below for a schematic picture of measles virus. Fig. 2 Showing the components and structure of measles virus. (5) The lipid envelope on the outside of the virus is acquired from the host cell during budding (13), because this outer layer is made up of host material it becomes difficult for the body’s immune system to detect the virus as non-self in the initial stages of infection enabling the virus to gain a foothold. Directly beneath the lipid envelop is the matrix (M), a protein that is important in virus replication as it facilitates the assembly of virus particles to the cell surface membrane during budding (5). The nucleoprotein (N) forms a protective sheath around the virus RNA called the nucleocapsid. The associated proteins P and L have been suggested to act as virus polymerase by some studies (12), helping in RNA replication. Then there are the two glycoproteins H and F. As their names suggest, they are responsible for anchoring the virus to the host cell and penetration of the cell membrane. The haemagglutinin binds (agglutinates) the virus to the host cell receptor (CD46, to be discussed later) and the fusion protein fuses the virus envelope with the cell membrane (5). Infection The infective process occurs in two key stages of attachment and fusion. In order for the virus genome to gain entry into the host cell and start replicating it needs to â€Å"catch† and â€Å"inject† host cells with its genome. The â€Å"catching† of host cells occurs when the virus haemagglutinin protein (H) attaches to the host cell receptor CD46. CD46 in the human cell act as a co-factor for serine protease degradation of C3b and C4b (14), these are the complement proteins of the immune system hence immunosupression by the measles virus. Studies (15) suggest that there exist more undefined virus receptors that enable the virus to attach to its host cells. The formation of syncytiae, cell-to-cell contact, also allows virus to spread to other cells (5). The â€Å"injecting† of host cells with the virus genome occurs during fusion, and the processes are less understood. It is thought that the same fusion processes occur for all enveloped virus, and studies (16) on human immune-deficiency virus (HIV) has shed some light into this. Two glycoproteins are involved, gp41 and gp120. gp41 is anchored onto the virus envelope and gp120 attaches to the host cell CD4 receptor next to the CCR5 co-receptor. Structural changes then occur whereby the gp41 is driven into the membrane of the host cell thereby linking the two cells (virus and host). The whole structure of gp41, gp120, co-rector CCR5 and CD4 receptor then collapses leaving the two membranes in apposition for fusion (16). Spread As discussed earlier, the virus enters the host through the respiratory tract, where it replicated in the epithelial cells. Then it infects cells of the immune system, monocytes are the mostly affected cells (6,7). You read "The pathogenesis of measles virus infection" in category "Essay examples" B and T lymphocytes are also infected but at less proportions as compared to monocytes. This amplification of the virus occurs in the lymph nodes of the host (5). Monocytes, B and T lymphocytes are cell of the peripheral blood and therefore circulate around the body, carrying with them the virus and spreading the infection to other parts of the body including the skin, gastro-intestinal tract, liver and the central nervous system. Disseminated virus proliferation occurs in the epithelial and endothelial cells of the blood vessels and other infected organs. Another mode of spread (mentioned earlier) is the formation of syncytia, not only do infected cells aggregate together, they can also form syncytia with non infected cells therefore infecting them in the process. Symptoms The symptoms of measles infections as mentioned earlier are fever, malaise, coryza, conjunctivitis, cough and Koplik’s spots in the oral cavity, later on the erythmatous maculopapular rash appears. These symptoms are tied with the immune’s response as the virus infection progresses. From day 0 when the virus first enters the host to around day 8, the first response from the immune system is the innate one, which is characterised by inflammation, giving rise to fever and general body malaise. As the virus continues to replicate in the epithelial cell of the host especially the nasal cavity (causing coryza), the trachea and bronchus (causing coughs), the nasolacrimal duct (causing conjunctivitis) and the oral epithelia cells (causing Koplik’s spots), it irritates these mucosal surfaces and cause their inflammation. The appearance of Koplik’s spots is diagnostic of measles (7) and it signals the appearance of early symptoms and viral load start to peak in th e blood (refer to fig 1 for the measles timeline in-host infection). These spots are transient and last for only about 3 to 4 days; also it is about this time that the adaptive immune response starts to kick in. At day 14 the viral load is at its peak and the adaptive immune response is fully operational and is clearing the pathogen from the system, the formation of the immune complex on the skin as the virus gets cleared result in the measles rash signalling cytotoxic T cell clearance of virus-infected cells (5, 7). After peak levels of the virus, following successful adaptive immune response, the virus levels drop and the immunological memory begins (7). In rare circumstances the virus can persist in the host, causing complications (17). One of these complications is the subacute sclerosing panencephalitis (SSPE), discussed below. Subacute sclerosing panencephalitis This is one of the complications of persistent measles virus infection; it affects the central nervous system of children who are infected by measles virus at a very early age (18). These children normally lack the maternal antibodies in their circulation to help combat the infection at its early stages. Studies (19) found that 50-75% of children who develop SSPE had measles infection before the age of two and also the prevalence rates of SSPE are 1:10 000 cases (9). This complication can take a very long time to manifest itself, with an average time of 8 years before SSPE symptoms appear and the reported range is between 9 months and 30 years (9). The disease leads to neurological deficits and eventually the patient dies (20). The other two measles complication worth mentioning are progressive measles inclusion body encephalitis (MIBE) which can occur in patients who are immunocompromised, and the post infection encephalomyelitis which is an autoimmune disorder that attacks the myel in sheath covering neurons. Recovery from measles (assuming opportunistic infections have not prompted medical intervention) requires both the humoral and cell mediated immune response. Cytotoxic T lymphocytes clear infected host cells and measles antibodies reduce free viral load by serum neutralisation (5) these antibodies can also be directed directly against the virus. The humoral response as usual is mostly for preventing re-infection and is involved in building immunity, a process taken advantage of by vaccine developers. After cytotoxic clearance of infected cells; there follows an immunologic type 2dominance where cytokines IL4, IL5 and IL10 are secreted by type 2 CD4+ T cells (21). Vaccination Many virus infections are untreatable, they are either self limiting, maim, or kill the host, so the only intervention that is available is to prevent infection in the first place. As noted from fig 1, after day 21 when the pathogen has been cleared, immunological memory is activated. This activation of immunological memory can only happen after the host has encountered the measles virus. Subsequent infections are met with a robust humoral response and the virus does not progress to cause infection. This is the basis of immunisation, the host immune system has to be introduced to the virus first, and as there is a risk of the virus overwhelming the immune system most virus used in vaccines are â€Å"controlled†. Attenuated virus vaccine Once the measles virus was isolated and cultivated by Enders and Peebles (5) it was then able to be manipulated. They found that the virus once cultured in chick embryos was attenuated in virulence and immunogenic enough to stimulate the host immune system to produce antibodies against it and remembering it (22). Work to produce a licensed measles vaccine begun in 1958 (5) and by 1963 the first licensed measles vaccine, RUBEOVAX ®, was available. In 1968 a more attenuated vaccine ATTENUVAX ® was licensed. As more vaccines for viruses e.g. mumps and rubella were developed there was a need to combine the doses into one single shot. In 1971 (5) a trivalent vaccine with all the three vaccines, measles-mumps-rubella was licensed. In recent times a fourth vaccine has been added to the MMR vaccine, resulting in a tetravalent vaccine MMRV (23). The fourth vaccine is a chicken pox vaccine, varicella. Other virus vaccines Other less favourable virus vaccines exist. Experiments were done on high titre vaccines by Sabin et al (5). These were aimed at infants who are at risk because they have circulating maternal measles antibodies which prevent vaccine uptake by neutralising it. The other vaccine, an inactivated measles virus vaccine produced by killing the virus in formalin was produced and licensed in 1963. It fell out of favour because the immunity if offered lasted for only one year and it had to be taken in three doses (5). With vaccination and great knowledge gained from studying measles it can be said that total eradication of the virus is possible. It is the beliefs and cultures of people that are slowing this up because they are not taking up vaccination. (2134 words excluding Refs. And plagiarism statement) References: Mrkic B, Pavlovic J, Rulicke T, Volpe P, Buchholtz C.J, Hourcade D, Atkinson J.P, Aguzzi A, and Cattaneo R. Measles virus spread and pathogenisis in Genetically modified mice, Journal of Virology (1998), 72, 7420-7427 World Health Organisation. Standardization of the nomenclature for describing the genetic characteristics of wild-type measles viruses. Weekly Epidemiological Record (1998);73:265–272 Clements CJ, Cutts FT. The epidemiology of measles: thirty years of vaccination. In: Meulen V, Billeter MA, editors. Measles Virus. Berlin: Springer Verlag, (1994) Lamb RA, Kolakofsky D. Paramyxoviridae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM, editors. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, (1996). p. 1177–1204 [Chapter 40] Hilleman M.R, Current overview of the pathogenesis and prophylaxis of measles with focus on practical implications, Vaccine (2002), 20, 651-665 Salonen, R., Ilonen, J., Salmi, A, Measles virus infection of unstimulated blood mononuclear cells in vitro: antigen expression and virus production preferentially in monocytes. Clin. Exp. Immunol. (1988). 71, 224–228. Heffernan J.M, and Keeling M.J, An in-host model of acute infection: Measles as a case study, Theretical Population biol, (2008), 73, 134-147 Saimi AA, Suppression of T-cell immunity after measles infection: is the puzzle solvedTrend Microbiol (1997) 5: 85–86 Takasu, T., Mgone, J.M., Mgone, C.S., Miki, K., Komase, K., Namae, H., Saito, Y., Kokubun, Y., Nishimura, T., Kawanishi, R., Mizutani, T., Markus, T.J., Kono, J., Asuo, P.G., Alpers, M.P. A continuing high incidence of subacute sclerosing panencephalitis (SSPE) in the Eastern Highlands of Papua New Guinea. Epidemiol. Infect. (2003) 131, 887–898. Griffin DE. Immune responses during measles virus infection. Curr Top Microbiol Immunol (1995);191:117–34. Naniche D, Varior-Krishnan G, Cervoni F, Wild F.T, Rossi B, Rabourdin-Combe C and Gerlier D. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus, Journal of Virology (1993) 67, 6025-6032 Horikami S.M and Moyer S.A, Structure, transcription, and replication of measles virus, Curr. Top. Microbiol. Immunol. (1995), 191, 35–50 Owen P, Jennifer E. Garrus and Wesley I. Sundquist. Mechanisms of enveloped RNA virus budding. Trends in Cell Biology, (2002),12, 569-579 Hughson F.M, Enveloped viruses: a common mode of membrane fusion?, Curr. Biol. (1997), 7. 565–569 Bartz R, Firschung R, Rima B, ter Meulen V, Schneider-Schaulies J. Differential receptor usage by measles virus strains. J Gen Virol (1998), 79:1015–1025. Chan DC, Kim PS. HIV entry and its inhibition. Cell (1998),93:681–684. Griffin DE, Bellini WJ. Measles virus. In: Fields BN, Knipe DM, Howley PM, editors. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996. p. 1267–1312 [Chapter 3. Dimova P, Bojinova V. Subacute sclerosing panencephalitis with atypical onset: clinical, computed tomographic and magnetic resonance imaging correlations. J Child Neurol (2000);15:258—61. Dunn RA. Subacute sclerosing panencephalitis. Pediatr Infect Dis J (1991); 10: 68-72. Rima K.B, and Duplex W.P, Molecular mechanisms of measles virus persistent. Virus research (2005), 111; 132-147 Karp CL. Measles, immunosuppression, interleukin-12 and complement receptors. Immunol Rev (1999); 168: 91–101. Katz SL, Enders JF. Immunization of children with a live attenuated measles virus. Am J Dis Child (1959); 98: 605–7 Vesikari T, Sadzot-Delvaux C, Rentier B, Gershon A. Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine. Pediatr Infect Dis J (2007) 26 (7): 632–8 How to cite The pathogenesis of measles virus infection, Essay examples

Saturday, December 7, 2019

Personal Branding in Business Process Samples for Students †MyAssignm

Question: Discuss about the Personal Branding in Business Process. Answer: Introduction Personal branding is the process that helps to establish the position and the image of the people in front of other people. Personal branding is also known as the brand name used by the individual for their products. So this personal branding is essential for the business and also for the people to ensure their market value and position. This paper reveals the personal brand of the student who is seeking for job or business project. In this paper, the online presence of the candidate and their personal brand is briefly discussed with the job profile that they want to pursue in future. Future job/Business project To get the appropriate job or business project for the starter is a difficult and challenging process. One has to be well branded for the job they want to pursue in the future. The students who have graduated recently find this challenging because to pursue the job they have to find that type of job which perfectly suits them. As for me the best job that I can pursue in future is the financial planner for the banking or corporate sectors. For this job, the main requirements that all the companies are wanting is the candidates have to be a permanent resident of Australia. The candidates have to be graduated and hold the degree in the financial management. The profile of the job is almost same for all the companies and to get this the candidates have to prepare themselves in that way. The companies also have the rules of contracting for at least three years and also the candidate should be flexible to work for the five days a week. Both the company AMP and MiQ offer the salary of $100k to $150k and both provide the full-time job to the candidates. So for the right candidates who have just passed their studies is the best to apply for this job. Self-Analysis The online presence is the existence of the business or the individual that are easily found by the help of online (Khedher, 2014). From the online presence, the main thing that came out is the lots of people who have the same name but profession and surname are different. As for me my profile show on the social media sites and it describe me as the students of financial management who passed this year. This profile may not be acceptable by the companies because to get allow in the company I have to create a strong profile which will improve my personal branding. The profile or the resume of the candidates must show their eligibility and also their degree properly. The resumes have to be in a way that the employer gets most of the information about the candidates after reading the resume. The resume of the candidates has to be simple, short but strong so that it becomes very easy for the employers to decide about the candidates appropriately. The personal branding of the candidates h as to be improved because all the companies want candidates who are socially responsible and also know how to handle the customers. At present, the candidate profile shows only the degree that the candidate has gathered from the university. But to impress the recruiter the candidate has to improve their profile with some more details about their past experience and personal views. SWOT Analysis Strengths Weaknesses Excellent communicational skill Well experienced in the field of financial advice and planning Hard working, flexible, friendly, formal and punctual Not familiar with the new software and programming There is gap of more than a year in the field of job Not willing to commit to a particular job Opportunities Threats To get adopted as per the business requirements To increase the profitability of the organization To provide best efforts in bringing positive outcomes for the organizations Not committed to a particular job The market competition of financial adviser and planner is very high The candidate needs to improve their nature of job hopping because any organization will not accept anyone as their employees who have the habit or nature of job hopping. From the SWOT analysis, it is clear that the candidate is hardworking and flexible but has the year gap and also has the nature of job hopping which needs to be improved by the candidate to impress the recruiter of the organization. Social Networking Profile Social media networking has become the important source for the individuals and the business person to do their brand promotion by the help of internet (Vallas, and Cummins, 2015). Social networking site is very easy to use and also it helps the business to reach customers from different cities. The most popular social networking sites in the world are Facebook, Twitter, Google+, LinkedIn, Pinterest, YouTube, Snapchat, Viber, etc. The two social networking sites that are most popular for the employees and the employers are the facebook and LinkedIn. In the profile of Facebook, people are able to see the detail about the person profile. The profile contains the name and the background of the people which allow the employers to decide about the candidate's eligibility. Facebook profile is the most popular social media network to gather information about a person and also the organizations recruit most of their employees from the facebook. LinkedIn is also same as facebook and here also the employers are able to gather information about the candidates. Both the social networking sites show the profile that the candidate is a financial management graduate and have passed graduation in the year 2016. The profile also shows that the candidate has two siblings and the candidate is the permanent resident of Australia. The profiles from these networking sites provide the maximum amount of information about the candidate and also this profile contains the image of the candidate so it becomes easier for the employers to recognize the candidate. LinkedIn provides the benefits to the students to build their professional network prepare them for the interview, get the referrals, extending the resumes, sharing the updates and so on. The students who use the LinkedIn get the professional attitude and for that, they can easily impress the employers to gain the job or the business project. The candidate image is clear from the LinkedIn profile that the candidate is best in the f ield of the financial management and also the candidate has the excellent communication skill. So the profile provides the every detail of the candidate that is required by the employers and if any changes are needed then the candidate need to improve the resume as per the current position of the candidate. Facebook is also the most popular social network site and for that, it also helps the candidate to improve their communication skill and also to gather knowledge about any specific topic. facebook provide the benefits of group where the candidate is able to discuss the job requirements and other topics. The employers are able to gather the correct information about the candidate from the facebook profile as this profile contain the personal background of the candidate and also it reflect the nature of the candidate. If the candidate needs to improve their online presence from the network sites then they have to simply update their profile and feed in the recent information about them in the social networking sites. As this two are very much important for the people for their personal branding in the market because these sites allow the people to update their images and also information and for that, they get recognized by the people from all over the world. These sites are accessible from anywhere in the world and also anyone can gather information about a person so this helps the people to improve their personal branding. From the profile of these two social networking sites, it is clear that the candidate is eligible for the job but the improvement that is needed in the profile is to update the profile so that the information in the profile is considered as the recent information of the candidate. Recommendations Conclusion Personal branding is the most important tool for the people to get an image of their position in the mind of other people. For the candidates who are searching for their future job, this personal branding will help them to create a good impression in front of the employers so that they easily get selected for the particular job role. It is recommended for the candidates that they have to analyze their weaknesses and try to improve it into the strengths. The candidate needs to keep their social networking profile up to date so that the recruiter gets the correct information about the candidate. This paper concludes that the candidate has to maintain and also upgrade their personal branding to impress the recruiter of the organization so that they get easily selected by the company. References Khedher, M., 2014. Personal branding phenomenon.International journal of information, business, and management,6(2), p.29. Vallas, S.P. and Cummins, E.R., 2015. Personal branding and identity norms in the popular business press: Enterprise culture in an age of precarity.Organization Studies,36(3), pp.293-319